In our research we studied the sub-facial drain for cerebrospinal fluid CSF leak prevention pediatric Lipomyelomeningocele, the total operated of all cases number was 26, through the working time between (January 2016 and January 2022), and the period of inserted case (14 days), with common presentations gait problems and urinary problems. A specimens of cerebrospinal fluid (CSF) must be acceptable of round the spinal-cord within lumber puncture. The surgery was performed with subtotal lipoma removal with preservation of neuronal integrity with nerve intraoperative monitoring, the drain size was 8 French and Radi Vac. There is approximately 125ml of cerebrospinal fluid present at one time, producing about 500ml each day. The action of cerebrospinal fluid is to absorb shocks and reduce their severity, or as a buffer cushion, providing mechanical protection from external stimuli and basic immunological protection for the brain as a whole in the skull. Cerebrospinal fluid also maintains a pivotal action as the brain's own regulator of cerebral blood flow. The time of drain was 8 days, under conditions represented by (no CSf output, no wound swelling, and no subcutaneous collection of the CSF) of the removal drain.