Objectives: Desflurane and sevoflurane are commonly used as inhaler agents in anesthesia. Although the protector effects of volatile anesthetics on the brain, heart and liver are well known, their effects on distant organ induced injuries in the lungs is not clearly understood. We examined the lungs, about the iscemia-reperfusion (I/R) distant organ damage for sevoflurane and desflurane. Methods: Diabetic animals were randomly divided into five groups, which had six animals. The groups were like this; first group was control group without diabetes. Second group was diabetic control group (DC), Third group was diabetic I/R ( D-I/R), Fourth group was diabetic I/R group with desflurane(D-I/R-D), and the fifth group was diabetic I/R group with sevoflurane (D-I/R-S) Results: Neutrophile infiltration/aggregation rate was fairly high in the DIR group when compared to other four groups DC, C, DIRS and DIRD. (p<0.0001, p<0.0001, p=0.00+95, p=0.005, respectively), Alveolar wall thickening in lung tissue was found significantly higher in the DIR group compared to the C and DC groups (p<0.0001, p<0.0001, respectively). The lung tissue injury score was found significantly higher in the DIR group compared to the C, DC, DIRD and DIRS groups (p<0.0001, p<0.0001, p=0.004, p=0.004, respectively), Conclusion: Sevoflorane and desflorane have positive effects on MDA, SOD and LTIS parameters in I/R damage on the distant organ lungs.